Phosphopantetheine adenylyltransferase
WebApr 15, 1999 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyses a rate-limiting step in coenzyme A (CoA) biosynthesis, by transferring an adenylyl group from ATP to 4′-phosphopantetheine, yielding dephospho-CoA (dPCoA). Each phosphopantetheine adenylyltransferase (PPAT) subunit displays a dinucleotide … WebNational Center for Biotechnology Information
Phosphopantetheine adenylyltransferase
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WebOct 3, 2003 · In coenzyme A, 4′-phosphopantetheine is covalently linked to an adenylyl group, whereas it is covalently linked to a serine hydroxyl group in acyl carrier proteins. 4′-phosphopantetheine is cofactor of enzymes that play a role in the biosynthesis of fatty acids, polypeptide antibiotics, and polyketides ( 2 ). WebMar 24, 2010 · To identify the phosphopantetheine adenylyltransferase sub-site bound by these inhibitors, two techniques were utilized: steady-state enzyme kinetics and a novel 19 F NMR method in which fluorine-containing fragments that bind the ATP and/or phosphopantetheine sites serve as competitive reporter probes. These data are …
Webpantetheine-phosphate adenylyltransferase Synonyms 3′-dephospho-CoA pyrophosphorylase PPAT dephospho-CoA pyrophosphorylase dephospho-coenzyme A pyrophosphorylase pantetheine phosphate adenylyltransferase Additional information <3, 4> (<3,4> with EC 2.7.1.24 part of a bifunctional enzyme with EC 2.7.1.24 [4,5]) [4, 5] CAS … WebInhibitors of 4′-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed...
WebJan 25, 2002 · Phosphopantetheine adenylyltransferase (PPAT) catalyzes a key regulatory step in the coenzyme A (CoA) biosynthetic pathway: 1 the reversible transfer of an … WebIn enzymology, a pantetheine-phosphate adenylyltransferase ( EC 2.7.7.3) is an enzyme that catalyzes the chemical reaction. ATP + 4'-Phosphopantetheine diphosphate + 3' …
WebJan 25, 2002 · Introduction. Phosphopantetheine adenylyltransferase (PPAT) catalyzes a key regulatory step in the coenzyme A (CoA) biosynthetic pathway: 1 the reversible transfer of an adenylyl group from ATP to 4′-phosphopantetheine (Ppant), which yields 3′-dephospho-CoA (dPCoA) and pyrophosphate. 2 CoA biosynthesis occurs in a series of …
WebFeb 7, 2024 · Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in complex with 3-(1H-indol-3-yl)propanoic acid at 1.6A resolution. img srcset iphoneWebMar 20, 2024 · Crystal structure of the complex of phospho pantetheine adenylyl transferase from Acinetobacter baumannii with two ascorbic acid (Vitamin-C) molecules. PDB DOI: 10.2210/pdb6JOG/pdb Classification: TRANSFERASE Organism (s): Acinetobacter baumannii Expression System: Escherichia coli Mutation (s): No Deposited: 2024-03-20 … img src widthWebPhosphopantetheine adenylyltransferase (PPAT, EC. 2.7.7.3) catalyzes an essential step in the reaction that transfers an adenylyl group from adenosine tri phosphate (ATP) to 4' … imgsru rc rc searchWebFeb 9, 2024 · Generally, CoA is synthesised from pantothenate (vitamin B 5) in five steps. 7 Phosphopantetheine adenylyltransferase (PPAT), a hexameric protein encoded by the coaD gene, catalyses the penultimate step—the transfer of an adenylyl group from ATP to 4′-phosphopantetheine, to form dephospho-CoA and pyrophosphate. img/src x onerror alert 1WebFeb 1, 2024 · Phosphopantetheine Adenylyltransferase (PPAT) is an enzyme that catalyzes the penultimate step in the biosynthesis of Coenzyme A (CoA), which is the active and physiologically functional form of ... img srcset pictureWebMar 2, 2024 · Phosphopantetheine Adenylyltransferase: A promising drug target to combat antibiotic resistance. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics … list of popes in order pdfWebOct 3, 2001 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in the coenzyme A pathway that catalyzes the reversible transfer of an adenylyl group from ATP … imgsrc.ru diaper tommy