Nettet1. mai 2024 · Thy1/αXβ2, Thy1/αMβ2, Thy1/CD97 in blood cells. Apart from the binding between Thy-1 and αVβ3 integrin, Thy-1 can bind to αMβ2 and αVβ5 integrin molecules to modulate intracellular signals. Thy-1 can also interact with itself, lipid raft microdomain proteins (reggie-1 and reggie-2), and SFKs (Src, Fyn, Lck, and Csk) to modulate … Nettet1. nov. 2024 · Thy-1, a GPI-anchored glycoprotein, contains an integrin-binding RGD-like motif (RLD) and regulates the phenotype of fibroblasts ( 15 – 18 ). Thy-1 is highly expressed on normal fibroblasts but is absent in activated fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis (IPF) fibroblastic foci ( 19, 20) and decreases with aging ( …
Astrocyte-to-neuron communication through integrin-engaged …
NettetThy-1 is an abundant neuronal glycoprotein of poorly defined function. We recently provided evidence indicating that Thy-1 clusters a beta3-containing integrin in … changing wheel bearings on utility trailer
Fibroblasts as immune regulators in infection, inflammation ... - Nature
Nettet1. mai 2011 · An interaction between integrin beta3 and THY1 has been reported to play a role in cell adhesion [27, 28]. The mRNA expression of various integrins has been … NettetFirst, Thy-1 binding to integrin alters its baseline avidity to ECM ligands. Second, Thy-1 facilitates the recruitment of membrane raft-residing signaling molecules such as Fyn kinase and the SFK regulator, Csk binding protein (Cbp), to FAs via its direct coupling of integrins and raft domains. Nettet12. jan. 2011 · In conclusion, THY1 might play a role in cell adhesion via binding to integrin beta3 in mouse ovaries. The present results suggest that THY1 localization may be affected by follicle-stimulating hormone in mouse ovaries. INTRODUCTION Follicles in mammalian ovaries constitute a single oocyte, granulosa cells, and theca cells. harley comet