WebSep 15, 2024 · Extracellular signal-regulated kinase (ERK) signaling plays a crucial role in regulating immune cell function and has been implicated in autoimmune disorders. To date, all commercially available inhibitors of ERK target upstream components, such as mitogen-activated protein (MAP) kinase/ERK kinase (MEKs), but not ERK itself. Here, we directly … WebApr 13, 2024 · Cytosolic access of SCPNs evaluated with GIGT assay (A) Schematic illustration of the workflow of GIGT assay. (B) Representative CLSM images of GFP nuclear translocation by incubating DEX-tagged compact (blue frame) or sparse (red frame) SCPNs with HeLa, HEK293, B16-F10 and 3T3-L1.
Late endosomes promote microglia migration via …
WebCytosolic gIVaPLA2is a critical enzyme in the generation of arachidonate metabolites and in induction of β2-integrin adhesion in granulocytes. ... Time-related phosphorylation and translocation of cytosolic gIVaPLA2to the nucleus was observed for PMNs stimulated with IL-8/CXCL8 in concentration sufficient to cause upstream phosphorylation of ... WebDec 20, 2024 · Fused in sarcoma/translated in liposarcoma (FUS) is an RNA-binding protein, and its mutations are associated with neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), through the DNA damage stress response, aberrant stress granule (SG) formation, etc. We previously reported that translocation of … can paypal friends and family be refunded
Cytosolic cleaved PINK1 represses Parkin …
WebMar 13, 2024 · In the present study, using liposome-leakage and cytotoxicity assays, LC-MS/MS–based proteomics, and CCF-4 FRET analysis, we obtained evidence that the N α -acetylation of the Thr-2 residue on... WebJul 16, 2024 · The availability of intracellular, stabilized β-catenin, a transcription factor coactivator, is tightly regulated; β-catenin is translocated into the nucleus in response to Wnt ligand binding to its cell membrane receptors. Here we show that Wnt signal activation in mammalian cells activates intracellular mobilization of connexin 43 (Cx43), which … WebNov 4, 2024 · In this context, bacterial two-component systems, termed AB toxins, use various protein-based membrane translocation mechanisms to deliver toxins into cells, and these mechanisms could provide new insights into the development of bio-based drug delivery systems. ... which is part of the cytosolic membrane fusion complex, termed … flame beast inside beats